A cleanroom is a controlled environment that has a low level of pollutants such as dust, airborne microbes, aerosol particles, and chemical vapors. The majority of cleanrooms are positive-pressure rooms that are designed to stop contaminants from entering the room. Air is introduced into the cleanroom after passing through a fan-powered HEPA filter that removes any small particles. This creates a pressurized room in which the air pressure within the room is greater than that outside the room. The air, along with any contaminants, is then pushed down towards the floor and out of vents in the walls of the room.

There are various ways of keeping a cleanroom safe and secure. Using the right equipment makes contamination control even easier to achieve. Choosing the right safety and security systems is key but every cleanroom is different, so what is right for one cleanroom might not be right for another. Although most cleanrooms are large, they can still differ in size, so choosing the right systems largely depends on the size of the cleanroom in question and what it it used for. There are various alarm systems, along with filtering systems that are effective at keeping things under control. There are also various steps that should be taken in order to increase contamination control.

There are many preventive procedures in place within a cleanroom environment. They include subjecting cleanroom staff to strict clothing regulations, and there is often a gowning room where the staff can change clothes under sterile conditions so as to prevent any particulates from entering from the outside environment. Certain areas in the cleanroom have more stringent measures than others: packaging areas, corridors, gowning rooms and transfer hatches incorporate strict contamination control measures in order to maintain cleanroom standards.

Centralized cleanroom alarm systems with audible and visual alerts, integrated into the cleanroom monitoring and controls systems can notify or start corrective actions to minimize any loss of product or process operations due to contamination by extraordinary events that may take place during cleanroom production cycles. Redundant air handling systems, filtration systems, refrigeration systems can be controlled to start up upon notifications of a failure in the primary systems. Centralized control systems with point of operation warning devices can notify operators of particulate levels, pressurization loss, air flow interruption and other contamination risks that occur