It is vital that safety and security rules and regulations are put into place for anybody who works in a cleanroom. Due to the high risks and danger involved in this kind of job role, it is vital that all workers know how to avoid any form of cleanroom contamination. Employers are required by law to ensure that work is being conducted safely, and to protect their workers from all work-related hazards, including exposure to infectious diseases. In a cleanroom environment, workers are at risk of contracting various diseases (for example, Ebola). Therefore, all workers have a responsibility to help reduce their risk of exposure to infectious pathogens. Workers should therefore take responsibility for their own actions by doing the following:

  • Attending education and training sessions.
  • Following safe work procedures, such as keeping good hygiene and wearing appropriate clothing.
  • Seeking immediate first aid and medical attention after an occupational exposure.
  • Reporting exposure incidents to supervisors or managers.
  • Refusing work that they have reasonable cause to believe will put themselves or others at risk.
  • Keeping a record of personal vaccinations, and ensuring that all their vaccinations are up to date.

Cleanroom contamination can arise from a number of sources. These may vary depending upon the type of cleanroom, its geographic location And the types of products processed. Nevertheless, these sources can generally be divided into the following groups:

  • People
  • Water
  • Air and ventilation
  • Surfaces
  • Transport of items in and out of clean areas 

 Most contamination within the pharmaceutical facility can be traced to humans working in cleanrooms. This is, in some way, evidenced from the association of microorganisms transient or residential to skin being the primary isolates from environmental monitoring in controlled environments. Human personnel shed high numbers of skin cells mostly as skin flakes. The cleanroom garments worn by personnel cannot contain all human detritus.

While filtration, special surfaces, and operating procedures establish and maintain cleanliness levels in a cleanroom, routine cleaning and maintenance are vital to keeping a facility clean. Inadequate or sloppy housekeeping can result in reduced product yields, compromised products or experiments, or higher operating costs.